We recommend that infants with PPHN secondary to parenchymal lung disease receive a dose of surfactant rich in surfactant protein-B (SP-B), such as calfactant - Infasurf® (ONY Inc, Amherst NY) or poractant-α - Curosurf® (Chiesi Farmaceutici, S.p.A, Parma, Italy). Here, SFTPB is linked to persistent fetal circulation syndrome.