DNM1L and Alzheimer disease: Moreover, Aβ gradually accumulates within the mitochondria of both living mouse models of AD and human AD brain sections, and Aβ has been found to directly interact with several mitochondrial proteins, for example, cyclophilin D (CypD), amyloid-β binding alcohol (ABAD) dehydrogenase, and dynamin-related protein 1 (Drp1) [8].