In correlation with IHC findings showing diminished expressions of all antioxidant proteins in BCC tissues, mRNA levels of the corresponding genes including CAT, GCLC, GCLM, NQO1, Nrf2, CuSOD, and MnSOD were also reduced in BCC tissues compared to epidermis of control subjects. This evidence concerns the gene NFE2L2 and skin basal cell carcinoma.