In addition, this study demonstrated decreased Nrf2 expression in BCC tissues compared to both adjacent nonneoplastic tissues of BCC patient and noncancerous tissues of control subjects which was in agreement with previous reports showing downregulation of Nrf2 and its target genes including NQO1 was associated with malignant transformation and upregulation of antioxidant mRNA including CAT, GCLC, GCLM, GPx, and NQO1 genes by Nrf2 overexpression was able to delay tumor growth [39]. This evidence concerns the gene GCLC and skin basal cell carcinoma.