LEP and metabolic dysfunction-associated steatotic liver disease: In addition, different studies showed apocynin as an effective pharmacological agent in ameliorating hyperlipidemia, hepatic steatosis [2], and insulin resistance [9], besides reducing inflammatory factors such as leptin, interleukin-6, and TNF-α [47], thereby indicating a protective role in diseases related to the MetS and in the progression of NAFLD.