SFTPD and pulmonary fibrosis: Niu et al., 2013, showed inhibitory effect of neferine on amiodarone-induced pulmonary fibrosis, due to its potency of anti-inflammation, inhibition of surfactant protein-D (SP-D), and balancing of the increased CD4+CD25+ regulatory T cells (Tregs) which may modulate Th1/Th2 imbalance by suppressing Th2 response [63].