CYBB and neoplasm: Additionally, in the semiquantitative analysis of Nox2 and p22phox by immunostaining, a statistically significant correlation was noted between the Nox2 IRS adjusted for tumor volume and baseline PAC (R = 0.503, P < 0.05), urinary aldosterone (R = 0.446, P < 0.05), and serum K+ (R = −0.550, P < 0.05).