Our investigations revealed a reduced astroglial and microglial activation in the hippocampus of TNFR1−/− and TNFR1-IL-6−/− mice after pneumococcal meningitis, whereas the infected IL-6−/− and WT mice showed no significant difference in glial cell activation. This evidence concerns the gene TNFRSF1A and pneumococcal meningitis.