As shown in Figures 4(a) and 4(c), the infection induced a strong increase of CRAMP mRNA expression in WT as well as IL-6−/− mice in the hippocampal formation and cortex (8.8 ± 2- and 9.2 ± 3.5-fold induction for WT in the hippocampus and cortex; 16.5 ± 2.1- and 6.6 ± 3-fold induction for IL-6−/− mice; Figures 4(a) and 4(c)). Here, CAMP is linked to infection.