The survival time after infection was significantly shorter in TNFR1−/−, IL-6−/−, and TNFR1-IL-6−/− (KO) mice compared to WT mice (36 (31/38), 40 (40/55), and 35 (30/40) versus 71 (57/75) h; medians (25th/75th percentiles); Mann-Whitney U test; p < 0.0001 for TNFR1−/− and TNFR1-IL-6−/− versus WT and p = 0.0018 for IL-6−/− versus WT; Figure 1(a)). Here, IL6 is linked to infection.