To find the possible correlation between the production of IL-17 and the expression of sTLR9 in/on the PMNs and macrophages in peritoneal cavity of the mice during septic peritonitis, we harvested the PLCs from the mice infected with 0.8, 1.6, and 2.4 × 108 CFUs of E. coli, respectively, at early stage of 8 hours after infection and detected their expression of IL-17 and sTLR9. The gene discussed is IL17A; the disease is septic peritonitis.