Primary transcription factors such as nuclear factor κB (NF-κB) and signal transducer and activator of transcription 3 (STAT3), which are driven by inflammatory cytokines including tumor-necrosis factor α (TNFα), interleukin-6 (IL-6), and interleukin-1β (IL-1β), are key orchestrators controlling inflammation-related cancer [9]. The gene discussed is TNF; the disease is cancer.