First, we comprehensively evaluated gene effects on the standard first-line treatment in NSCLC, platinum-based chemotherapy, and the indicators covered both treatment efficacy and clinical prognosis (ORR, OS, and PFS); second, we made a statistical progress when evaluating the predictive values of ERCC1 polymorphisms for platinum-based chemotherapy in NSCLC; third, all of our included studies were of high quality and no evident publication bias was observed. Here, ERCC1 is linked to non-small cell lung carcinoma.