RUNX2 and lymphoma: However, the Runx family are not merely cofactors for Myc oncogenesis; CD2-Runx2 transgenic mice display dose-dependent predisposition to lymphoma [11, 13] and strongly synergistic lymphoma development in combination with other oncogenes such as Pim-1 and v-Myb, as well as with loss of p53 [10].