PARP cleavage induction in the high BCL-2-expressing cell lines was already observed after treatment with only 7.5 nmol/L ABT199, while for the low BCL-2-expressing neuroblastoma cell lines PARP cleavage was only detected in SKNAS after treatment with 10 μmol/L ABT199 (Figure 2A). The gene discussed is BCL2; the disease is neuroblastoma.