ITGB2 and Leukocyte adhesion deficiency type I: LAD-I patients suffer from recurrent and life-threatening infections that appear early in childhood.4 Two different phenotypes of LAD-I have been described5: a severe phenotype, when levels of CD18 expression are lower than 2% of normal level, and a moderate phenotype, when levels of CD18 expression are 2–30% of the normal level.