Remarkably, 48 genes at different levels of the PI3K/Akt signaling pathway were targeted by the tumour suppressor miRs let-7a, let-7d, let-7f, miR-16, and/or miR-143 (Fig. 7) whereas 11 genes of the p53 signaling pathway were targeted by the oncomiRs miR-21, miR-29b, miR-142-3p and miR-203 (Fig. 8). The gene discussed is AKT1; the disease is neoplasm.