KLF1 and Schnyder corneal dystrophy: Therefore these data highlight the critical role played by potent negative regulators of HbF such as MYB, KLF-1 and BCL11A and demonstrate that miRNAs provide a viable therapeutically responsive tier of HbF production for SCD treatment (Fig. 7), importantly while sparring the undruggable nature these transcription factors in non-erythroid cells [73].