FGFR3 and non-small cell lung carcinoma: Additionally, increased FGFR3 expression, mutations and gene fusions were observed in primary human NSCLC, and in cell lines derived from these tumors (Liao et al., 2013; Majewski et al., 2013); however, it has not been proven that FGFR3 activation is a driver event in these cancers.