We also detected C1q on the cellular elements synaptophysin and S100b indicating C1q is also deposited at the motor nerve terminal and terminal Schwann cell in the intercostal muscle of ALS donors (Additional file 1: Figure S1B, D, arrows) but not in controls (Additional file 1: Figure S1A, C). The gene discussed is SYP; the disease is amyotrophic lateral sclerosis.