CD4 and Chronic colitis: A non genotoxic mutant carrying a deletion of the cblA gene is impaired in its ability to prevent colitis in two models: the Dextran Sodium Sulphate (DSS)-induced acute colitis in rats and a T-cell dependent model of chronic colitis induced by the adoptive transfer of naive CD4+ CD45RBhigh T cells in immunocompromised SCID mice [60].