CACNA1C and Timothy syndrome: Even in a database as carefully constructed as SFARI Gene [52], one can imagine a number of possible sources of bias, such as: 1) The tendency to study genes that are related to genes already implicated in ASDs–for example, the identification of a relationship between CACNA1C and the ASD-related Timothy Syndrome sparked an interest in calcium channels more broadly, leading to an uptick of findings about calcium channel genes in relation to ASDs.