Given the pivotal role that IL-22 can play in immune-stromal cell communication and the disparite data on this cytokine in the response to infection (and general lack of data in relation to helminths) and regulation of inflammation, the current study assessed the impact of the absence of IL-22 in (1) the expulsion of H. diminuta from its non-permissive mouse host and the concomitant immune response, and (2) whether the anti-colitic effect of infection with H. diminuta was modified. The gene discussed is IL22; the disease is infection.