CRP and sleep apnea syndrome: In this complex relation beetween SDB and MPV, SDB-related hypoxemia and/or sleep fragmentation may lead to a systemic inflammation as supported by the higher C reactive protein (CRP) levels in children with SDB,[13] in particular when a neurocognitive dysfunction has developed.[14] In this perspective, another potential interesting factor might be represented by vitamin D which may control the release of proinflammatory cytokines and its deficiency has been associated with higher CRP [15] and MPV.[16]