MiR-486 has been shown to be controlled by the transcription factor MRTF-A at a promoter immediately upstream of exon 39a within the ANK1 gene, which also allows for the muscle-specific production of sAnk1 (ANK1.5).47, 50, 51 Concurrently, miR-486 has also been shown to be regulated by a p53 promoter upstream of the ANK1 gene in lung cancer.29 Our work shows that p53 controls both miR-486 and full-length ANK1 expression following DNA damage. This evidence concerns the gene MRTFA and lung cancer.