DVL2 and kidney disorder: Wnt/β-catenin signaling cascade exhibits a pivotal function in the progression of DN and other proteinuric kidney diseases.26, 27, 28, 29 Our preliminary studies have also found that phosphoprotein disheveled 2 (DVL-2), an integral part of Wnt signaling,30 is associated with and upregulated by β-arrestins in podocytes with HG treatment.