For example, breast cancer (BC) cells are relatively refractory to ionizing radiation (IR)-induced DNA damage and apoptosis.1 Combinations that use radiation with biological modifiers constitute a main research objective for oncologist,2 and it is widely accepted that blocking DNA repair mechanisms improves radiation therapy in refractory BCs, especially in those with p53 mutations that exhibit increased resistance to apoptosis. The gene discussed is TP53; the disease is breast cancer.