OPA1 and retinal degeneration: Thus, the modulation of mitochondrial dynamics by either increasing fission or decreasing fusion leads to the isolation and mitophagic elimination of damaged mitochondria.55 Consistent with PINK1/Parkin expression, increased mitofission suppressed retinal degeneration in the TrpP365 mutant, whereas the induction of mitofusion via the expression of Opa1 had the opposite effect.