SLC8A1 and retinal degeneration: As previously reported, overexpression of the reciprocal Na+/Ca2+ exchanger CalX largely suppressed retinal degeneration in the TrpP365 mutant background, which suggests that the degeneration of TrpP365 mutant photoreceptor cells results from increased cellular calcium26, 29 (Figures 2a, b, e, and 2f).