Upregulation of antiapoptotic proteins has been reported in some hematological malignancies,17, 18 stimulating the development of potent BCL-2i.11, 12 Importantly, it was reported that BCL-2 overexpression in lymphoid malignancies inhibited apoptosis through BIM sequestration19, 20 and that BCL-2i induced apoptosis by disrupting the BCL-2/BIM complex. This evidence concerns the gene BCL2 and hematologic disorder.