This implicated BIM in the synergistic killing of B-ALL cells by trametinib and ABT-263, and accordingly, we show that when BIM was depleted, trametinib no longer synergized with ABT-263 to kill BV173R or 697 cells (Figures 3g and h; Supplementary Figures S7a and b). Here, BCL2L11 is linked to acute lymphoblastic leukemia.