Interestingly, pro-inflammatory, anti-tumor genes (cd86, tnfα, inos, il1β and il6), whose expression is not different in the two cerebral hemispheres, regardless of tumor presence (with the only exception being represented by inos), are remarkably increased in the glioma ipsilateral hemisphere of TRAM-34-treated mice. The gene discussed is TNF; the disease is central nervous system cancer.