MMP12 and central nervous system cancer: Similar results were obtained when CD11b+ cells were isolated from tumoral tissue obtained from GBM patients undergoing surgery: upon TRAM-34 treatment, these cells had a significant reduction of human anti-inflammatory markers (CD163, MMP12) and a significant increase of human pro-inflammatory markers (CXCL10, IL12A, NOS2 and TNF)21 (Figure 1c), confirming in human GBM the data obtained in glioma-bearing mice.