KCNN4 and central nervous system cancer: We have previously shown that GCM exposure modulates microglia migration and phagocytic activity and that KCa3.1 inhibition abolished these effects.14 We confirmed these data by performing migration, invasion and phagocytosis assays on primary murine microglia exposed to medium conditioned by GL261 (Figure 4a), U87MG and GL15 (Supplementary Figure S2) glioma cell lines, in the presence of TRAM-34, finding that KCa3.1 block inhibited all the activities potentiated by GCM (Figure 4a).