In addition, after screening 120 inflammatory molecules in CSF and serum of AD, MCI and healthy controls through protein-array analysis, a combination of soluble IL-6 receptor (sIL-6R), tissue inhibitor of metalloproteinases-1 (TIMP-1) and soluble TNF-α receptor I (sTNFR-I) in CSF was found to provide the best prediction to AD among other molecules [115]. This evidence concerns the gene IL6R and Alzheimer disease.