MBD2 and cancer: Beside those overlapping interactions, we also identified new SNP-SNP interactions that were relatively strong, which included MBD2_02 (rs1145315) and GSTM3_01, MBD2_02 and AXIN2_02. To further check the biological functions, MBD2 was methl-CpG-binding domain protein 2, which belonged to methyl-CpG-binding domain (MBD) and had been previously identified possessing the function of activating certain promoters by de-methylation, particularly in cancer 39].