A further large difference in estimated effect size between CKB (or AGEN-T2D + CKB) and Europeans, for ADCY5 rs11708067 (OR [95% CI]: 1.92 [1.28, 2.88] vs 1.10 [1.06, 1.15]), likely reflects low power and uncertainty in effect size in CKB: neither the difference nor the diabetes association itself was significant after correction for multiple testing. The gene discussed is ADCY5; the disease is diabetes mellitus.