ROC analysis to assess prediction of diabetes in CKB by GRS-T based on 52 type 2 diabetes risk variants genotyped in the majority of samples showed that, compared with the unweighted risk score (C statistic [95% CI]: 0.574 [0.567, 0.580]), there were significant improvements in discrimination when using risk scores based on weights from previous meta-analyses, TransEthnic in particular (0.590 [0.583, 0.597], p = 3.6 × 10−20, TransEthnic vs unweighted). This evidence concerns the gene CKB and type 2 diabetes mellitus.