INS and Hyperglycemia: Insulin-producing cells (IPCs) in adult flies synthesize three ILPs (Ilp2, Ilp3 and Ilp5; larval IPCs also produce Ilp1), and ablation of the IPCs or genetic deletion of Ilp2 causes hyperglycemia (Grönke et al., 2010; Haselton et al., 2010; Ikeya et al., 2002; Rulifson et al., 2002).