Subtle but persistent changes in mediators of GPCR signaling (Gng7 and regulator of G-protein signaling 2 [Rgs2]) can impact anxiety and aggressive behaviors21, 30, and alterations in cAMP, PLC, and Rho GTPase-mediated signaling may cause abnormal neural activity in IP3K-A-deficient amygdala circuitry. This evidence concerns the gene HSPG2 and Anxiety.