Accordingly, treatment with nanoparticles loaded with recombinant IκBα and curcumin, a natural polyphenol that inhibits the phosphorylation of IκBα, has been shown to decrease the expression of NFκB target genes such as CCND1, CCNE1, BCL2L1 and COX2, thereby inducing apoptotic cell death in a glioblastoma cell line17. The gene discussed is NFKBIA; the disease is glioblastoma.