Considering the aberrant apoptosis and abnormal differentiation of keratinocytes in the PMVK-deficient lesional tissues, further studies will likely reveal the relationship between the cholesterol/isoprenoid biosynthetic pathway and the formation of cornoid lamellae in patients with PMVK-deficiency-associated DSP. This evidence concerns the gene DSP and hyperinsulinemic hypoglycemia, familial, 4.