Over the last 4 years, several studies have identified an array of heterozygous nonsense, frameshift, and missense mutations in the gene encoding proline-rich transmembrane protein 2 (PRRT2) in a large number of cases affected by different paroxysmal disorders such as benign familial infantile seizures, infantile convulsion choreoathetosis, migraine, hemiplegic migraine, paroxysmal kinesigenic dyskinesia/choreoathetosis, benign familial infantile seizures/epilepsy, and episodic ataxia (Chen et al., 2011, Lee et al., 2012; for review, see Ebrahimi-Fakhari et al., 2015). This evidence concerns the gene PRRT2 and migraine disorder.