ATRX and alpha thalassemia spectrum: In addition to the analysis of 82-kDa ChAT and SATB1, we also included a ChIP-seq dataset for Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) (NCBI GEO database accession number: GSE22162)46, as this protein is involved in chromatin reorganization, but has not previously been associated with S/MARs46, 47, 48.