In addition to these GO terms we also identified several genes previously identified by a meta-analysis of genome wide association studies assessing AD risk39, including BIN1, CR1, EFNA5, GAB2, MAGI2, MTHFD1L and PRUNE2. We also found several APP binding and metabolism related genes in several conditions (Table 1). The gene discussed is MTHFD1L; the disease is Alzheimer disease.