IFNG and infection: In terms of asymptomatic (AI, SRI, and III) and subclinical oligosymptomatic (SOI) infection profiles, a number of studies have confirmed the beneficial Th1 actions of IFN-γ and IL-12 cytokines in overcoming the Th2-inhibiting effect of IL-10 in cultured-stimulated PBMC from asymptomatic individuals with positive DTH reactions [12].