Moreover, measurement of granulocyte colony-stimulating factor (GCSF) is an important parameter for GSD-1b diagnosis, as G-CSF may increase the number and improve the function of circulating neutrophils, and G-CSF may improve the symptoms of Crohn-like inflammatory bowel disease in individuals with GSD-1b [30, 31]. The gene discussed is CSF3; the disease is glycogen storage disease Ib.