MMP2 and adenoma: There was no difference in the MMP-2 score between macroadenomas (3.0 ± 0.3) and microadenomas (2.1 ± 0.4; p > 0.05), and also no difference between the functioning adenomas (2.8 ± 0.3) and nonfunctioning adenomas (2.8 ± 0.3; p > 0.05) [5].