FCGR2B and rheumatoid arthritis: RA patients with FcγRIIb 695T>C variant had significantly more radiologic joint destruction than those carrying the FcγRIIb wild-type alleles, which suggested that the FcγRIIb variant was an independent and by far the strongest predictor of radiologic joint damage by altering its function failed to display the inhibitory [5, 6].