The remodelling of the ECM of the tumour leading to realignment and its stiffening is modulated through integrins and Rho-Rho associated protein kinase (ROCK) by several molecules such as MMPs, syndecan-1, lysyl-oxidase (LOX), yes-associated protein (YAP), caveolin-1, transforming growth factor-beta (TGF-beta), fibroblast activation protein (FAP), and platelet-derived growth factor (PDGF), but also by physical conditions such as stiffness, strain, or interstitial flow [38]. Here, LOX is linked to neoplasm.