TTN and Duchenne muscular dystrophy: Interestingly, some of the biomarkers that were found highly elevated in serum of DMD patients and mdx mice compared to their respective controls were found unchanged in their levels when comparing the proteome profiles of dystrophic muscle tissue to normal muscle tissue in the mdx mouse model except for titin, fatty acid binding protein 3, lactate dehydrogenase B (LDHB), and Troponin I fast skeletal muscle were found slightly decreased in dystrophic muscle relative to healthy muscle [51].