Recently Huzzy et al. [74] evaluated the association between peri-partum (3 weeks before calving to 10 days after calving) markers of stress (cortisol), inflammation (Hp), and energy balance (NEFA and BHBA) and milk yield and reproductive performance in HF cows and found negative association of Hp and other markers with milk yield and reproductive performance. The gene discussed is HP; the disease is hydrops fetalis.