Indeed, it is known that the dysregulation of CH metabolism is associated with the severity of fatty liver disease/NAFLD (Bashiri et al., 2013, Min et al., 2012) and that menopause increases the prevalence of fatty liver disease/NAFLD (Gutierrez-Grobe et al., 2010), as well as a number of associated pathologies. This evidence concerns the gene C4B and fatty liver disease.