The main findings of this study are: (1) stimulation of human bone marrow-derived MSCs with IFN does not alter their differentiation capacity; (2) uMSCs and iMSCs engraft in infarct myocardium and (3) neither treatment with uMSC nor iMSCs improves cardiac function after MI. The gene discussed is IFNA1; the disease is myocardial infarction.