A Genome-Wide Association Meta-analysis of Neuropathologic Features of AD identified 9 new loci, involving the genes ABCA7, BIN1, CASS4, CD33, MEF2C, MS4A6A, PICALM, SORL1 and ZCWPW1, that are significant in regards to AD pathogenesis [30]. This evidence concerns the gene PICALM and Alzheimer disease.