However, the parent genes are significantly upregulated in BLCA (P=8.15e–49), BRCA (P=5.07e–204), GC (P=5.49e–206) and HCC (P=1.47e–32) and downregulated in CRC (P=1.94e–4) and KCA (P=4.51e–07), but unchanged in PRAD (P=0.4320). Here, CSN3 is linked to bladder transitional cell carcinoma.