In follicular thyroid cancer cells, leptin had more dramatic effects in gene expression than those of OB3; for example leptin increased the expression of PCNA and c-Myc in FTC236 cells but decreased the expression of PCNA, c-Myc and MCL-1 in FTC238 cells (Figure 1E). The gene discussed is MYC; the disease is thyroid gland follicular carcinoma.