PTEN and chronic myelogenous leukemia, BCR-ABL1 positive: Recently, we demonstrated that Curcumin treatment of Chronic myelogenous leukemia (CML) cells caused a selective sorting of miR-21 in exosomes and a concomitant decrease of this miRNA into the cells, thus leading to the upregulation of PTEN and the subsequent inhibition of leukemic cell growth [4].