As an effort to understand the mechanism of action of BKM1644 in PCa cells, we specifically examined the effect of BKM1644 on Stat3 signaling and found that this compound selectively inhibits the luciferase activity of pSurvivin-Luc1430, which contains at least two Stat3 cis-elements, suggesting a possible role of Stat3 as a mediator for the inhibitory effect of BKM1644 on survivin transcription. Here, BIRC5 is linked to posterior cortical atrophy.