Indeed, the presence of BKM1644 in cell cultures, as well as in C4-2 xenografts, attenuated docetaxel-induced induction of survivin, which could contribute to the observed efficacy of BKM1644 in retarding tumor growth in mouse bone and activating apoptosis in vivo, as evidenced by increased TUNEL staining in the combination group. The gene discussed is BIRC5; the disease is neoplasm.